Here at The Epec Clinic, our doctors provide Esketamine for the treatment or relief of anxiety, depression and or addiction. For information call us 443-559-8354
Ketamine and Esketamine are closely related compounds, but they have some differences in their chemical structure, effects, and uses. Here’s a breakdown:
Ketamine
Chemical Structure: Ketamine is a racemic mixture, meaning it contains equal parts of two enantiomers: R-ketamine and S-ketamine (esketamine).
Uses: Initially developed as an anesthetic, ketamine is also used off-label for treatment-resistant depression and other mood disorders. It can be administered intravenously, intramuscularly, or intranasally.
Mechanism of Action: It works primarily as an NMDA receptor antagonist, which leads to increased glutamate release and can promote neuroplasticity. Its rapid antidepressant effects are thought to be due to these mechanisms.
Side Effects: Common side effects include dissociation, hallucinations, increased blood pressure, and potential for abuse.
Esketamine
Chemical Structure: Esketamine is the S-enantiomer of ketamine, making it more potent in some of its effects compared to the racemic mixture.
Uses: Esketamine is FDA-approved for treatment-resistant depression and is available as a nasal spray (Spravato). It’s used in conjunction with an oral antidepressant.
Mechanism of Action: Similar to ketamine, esketamine also acts as an NMDA receptor antagonist but may have a faster onset of action and a different safety profile.
Side Effects: While it shares many side effects with ketamine, esketamine has been designed with a focus on safety and efficacy in a clinical setting. Monitoring during and after administration is often required.
Summary
Potency: Esketamine may be more potent than ketamine in some aspects.
Administration: Esketamine is primarily administered as a nasal spray, while ketamine can be given in multiple forms.
Approval: Esketamine has specific FDA approval for depression, whereas ketamine is often used off-label.
Both have shown promise in treating depression, but the choice between them may depend on individual patient needs, the setting of administration, and specific medical guidelines. Always consult a healthcare provider for personalized advice.
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